IL-4 and IL-5 Secretions Predominate in the Airways of Wistar Rats Exposed to toluene Diisocyanate Vapor

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IL-4 and IL-5 Secretions Predominate in the Airways of Wistar Rats Exposed to Toluene Diisocyanate Vapor

OBJECTIVES We established a Wistar rat model of asthma caused by toluene diisocyanate (TDI) exposure, and investigated the relationship between TDI exposure concentrations and respiratory hypersensitivity, airway inflammation, and cytokine secretions in animals, to better understand the mechanism of TDI induced occupational asthma. METHODS Wistar rats were exposed to two different concentrati...

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Eosinophil infiltration in airways of mice exposed to toluene diisocyanate.

Toluene diisocyanate (TDI) is a chemically reactive low-molecular-weight compound widely used in industries as a polymerizing agent in the production of polyurethanes. TDI has been reported as one of the most important causes of occupational asthma. Clinical investigations have shown that asthma is an inflammatory disorder of the airways and is referred to as chronic eosiniopilic bronchitis . E...

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Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity.

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Antibodies to toluene diisocyanate in an environmentally exposed population.

Residents living near a polyurethane foam manufacturing facility expressed concern to health officials over chemical emissions from the plant. Environmental monitoring of ambient air near the plant indicated the presence of toluene diisocyanate (TDI), which was used in foam production. Health officials collected blood samples from 113 residents and analyzed the blood sera for antibodies to TDI ...

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ژورنال

عنوان ژورنال: ISEE Conference Abstracts

سال: 2014

ISSN: 1078-0475

DOI: 10.1289/isee.2014.p2-445